Teacher self-efficacy (TSE) is related to teachers’ job satisfaction, retention, motivation to improve, and work-related stress. Using data from the 2018 Teaching and Learning International Survey (TALIS), we investigated the impact of innovative campus culture and preparation for teaching cross-curriculum skills on TSE. Data indicated that working at innovative campuses had small effects on TSE in classroom management (β = .12), instruction (β = .06), and student engagement (β = .17). Teachers’ preparation to teach cross-curriculum skills had small to medium effects on TSE in classroom management (β = .20), instruction (β = .34), and student engagement (β = .30).